Affinity DataIC50: 0.0330nMAssay Description:Displacement of [3H]]nociceptin from human ORL1 receptor high affinity binding site expressed in African green monkey COS7 cells after 90 mins by top...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0464nMAssay Description:Displacement of [3H]NOC from human ORL1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0590nMAssay Description:Displacement of [3H]]nociceptin from human ORL1 receptor high affinity binding site expressed in African green monkey COS7 cells after 90 mins by top...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0803nMAssay Description:Displacement of [3H]NOC from human ORL1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0840nMAssay Description:Binding affinity to human ORL1 receptor expressed in African green monkey COS7 cells assessed per mg protein after 90 mins by Scatchard plot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.120nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.122nMAssay Description:Displacement of [3H]-NC from human ORL1 receptor expressing HEK-293 cell membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.150nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:Displacement of [3H]nociceptin from recombinant ORL1 receptor expressed in COS7 cells by competitive receptor binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.220nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.270nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.286nMAssay Description:Displacement of [3H]-NC from human ORL1 receptor expressing HEK-293 cell membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.290nMAssay Description:Binding affinity to ORL1 receptor (unknown origin) by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.310nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.353nMAssay Description:Displacement of [3H]-NC from human ORL1 receptor expressing HEK-293 cell membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.471nMAssay Description:Displacement of [3H]-NC from human ORL1 receptor expressing HEK-293 cell membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.520nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.520nMAssay Description:Displacement of [3H]-NC from human ORL1 receptor expressing HEK-293 cell membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.520nM EC50: 0.310nMAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Displacement of [3H]nociceptin from human ORL1-Galpha fusion receptor in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.610nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.610nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.630nMAssay Description:Displacement of [125I][Tyr14]nociceptin/orphanin FQ from human nociceptin opioid receptor expressed in CHO cell membranes after 1 hr by microplate sc...More data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Displacement of [3H]]nociceptin from human ORL1 receptor expressed in African green monkey COS7 cells after 90 mins by topcount analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.660nMAssay Description:Displacement of [3H]nociceptin from human ORL1-Galpha fusion receptor in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.660nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.660nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.720nMAssay Description:Displacement of [3H]nociceptin from recombinant ORL1 receptor expressed in COS7 cells by competitive receptor binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.767nMAssay Description:Displacement of [3H]NOC from human ORL1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.789nMAssay Description:Displacement of [3H]NOC from human ORL1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.790nMAssay Description:Displacement of [3H]nociceptin from human ORL1-Galpha fusion receptor in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nM EC50: 2.40nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 0.810nM EC50: 1.30nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 0.810nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 0.833nMAssay Description:Displacement of [3H]-NC from human ORL1 receptor expressing HEK-293 cell membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.920nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.980nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1nM EC50: 1.10nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]]nociceptin from human ORL1 receptor expressed in African green monkey COS7 cells after 90 mins by topcount analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair